2006 marked the first year in the recorded history of Morissette's musical career that she had not a single concert appearance showcasing her own songs, with the exception of an appearance on The Tonight Show with Jay Leno in January when she performed "Wunderkind". On April 1, 2007, Morissette released a tongue-in-cheek cover of The Black Eyed Peas's selection "My Humps," which she recorded in a slow, mournful voice, accompanied only by a piano. The accompanying YouTube-hosted video, in which she dances provocatively with a group of men and hits the ones who attempt to touch her "lady lumps," had received over fifteen million views by June 7. Morissette did not take any interviews for a time to explain the song, and it was theorized that she did it as an April Fools' Day joke. Black Eyed Peas vocalist Stacy "Fergie" Ferguson responded by sending Morissette a buttocks-shaped cake with an approving note. On the verge of the release of her latest album, she finally elaborated on how the video came to be, citing that she became very much emotionally loaded while recording her new songs one after the other and one day she wished she could do a simple song like "My Humps" in a conversation with Guy Sigsworth and the joke just took a life of its own when they started working on it.

Morissette performed at a gig for The Nightwatchman, a.k.a. Tom Morello of Rage Against the Machine and Audioslave fame, at the Hotel Café in Los Angeles in April 2007. The following June, she performed "The Star-Spangled Banner" and "O Canada", the American and Canadian national anthems, in Game 4 of the Stanley Cup Finals between the Ottawa Senators and the Anaheim Ducks in Ottawa, Ontario. In early 2008, Morissette participated in a tour with Matchbox Twenty and Mute Math as a special guest.

Morissette's seventh studio album, Flavors of Entanglement, which was produced by Guy Sigsworth, was released in mid 2008. She has stated that in late 2008, she would embark on a North American headlining tour, but in the meantime she would be promoting the album internationally by performing at shows and festivals and making television and radio appearances. The album's first single was "Underneath", a video for which was submitted to the 2007 Elevate Film Festival, the purpose of which festival was to create documentaries, music videos, narratives and shorts regarding subjects to raise the level of human consciousness on the earth.

As of May 2008, Morissette was halfway through writing a memoir that will focus on women's issues. It will have chapters on sexuality, beauty, relationships and work and was partially inspired by young women who regularly come up to her and tell her their stories of personal pain. In 2008, she participated in a music album called Songs for Tibet, singing an acoustic rendition of Versions of Violence from Flavors of Entanglement. The song was recorded in her dressing room on a tour stop in Cologne, Germany. The album pledged support for Tibet and the current Dalai Lama Tenzin Gyatso. The release of the album coincided with the start of the 2008 Summer Olympics in the People's Republic of China that celebrated its opening on August 8. On October 3, 2008, Morissette released the video for her latest single, "Not as We".

• "House M.D." (1 episode, 2007)
  ... aka House (South Africa: English title) (USA: short title)
       - 97 Seconds (2007) TV episode ("Not As We")
• I Could Never Be Your Woman (2007) (writer: "Ironic")
• "The Office" (1 episode, 2006)
  ... aka The Office: US Version (Australia)
       - A Benihana Christmas (2006) TV episode (writer: "You Oughta Know")
• The Devil Wears Prada (2006) (performer: "Crazy")
• The Break-Up (2006) (writer: "You Oughta Know") (performer: "You Oughta Know")
• Clerks II (2006) (writer: "Everything") (performer: "Everything")
• "Shminiya, Ha-" (2 episodes, 2005-2006)
  ... aka The Eight (International: English title)
       - Long Story (2006) TV episode (performer: "Thank U") ("Thank U")
       - Be'ayot Ba-Derech (2005) TV episode (writer: "Forgiven") (performer: "Forgiven")
• The Chronicles of Narnia: The Lion, the Witch and the Wardrobe (2005)
  (writer: "Wunderkind" (2004)) (performer: "Wunderkind" (2004)) (producer: "Wunderkind" (2004))
  ... aka The Chronicles of Narnia (International: English title: short title)
• De-Lovely (2004) (performer: "Let's Do It, Let's Fall in Love" (1928))
• Beth - Palau de la música catalana (2004) (V) (writer: "Head Over Feet")
• "Smallville" (1 episode, 2004)
  ... aka Smallville Beginnings (USA: rerun title)
  ... aka Smallville: Superman the Early Years (UK: promotional title)
       - Resurrection (2004) TV episode (performer: "Everything")
• "Celebridade" (2003) TV series (unknown episodes)
• "Dawson's Creek" (2 episodes, 1999-2003)
       - ...Must Come to an End (2003) TV episode ("Hand In My Pocket")
       - Parental Discretion Advised (1999) TV episode ("That I Would Be Good")
• "Operación triunfo" (1 episode, 2003)
  ... aka O.T. (Spain: promotional abbreviation)
       - Episode #2.12 (2003) TV episode (writer: "Ironic")
• Stella Shorts 1998-2002 (2002) (V) (writer: "Thank U") (performer: "Thank U")